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Exploring the Role of Hepcidin, an Antimicrobial and Iron Regulatory Peptide, in Increased Iron Absorption in β‐Thalassemia
Author(s) -
BREDA LAURA,
GARDENGHI SARA,
GUY ELLA,
RACHMILEWITZ ELIEZER A.,
WEIZERSTERN ORLY,
ADAMSKY KONSTANTIN,
AMARIGLIO NINETTE,
RECHAVI GIDEON,
GIARDINA PATRICIA J.,
GRADY ROBERT W.,
RIVELLA STEFANO
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1345.069
Subject(s) - hamp , hepcidin , hemochromatosis , hereditary hemochromatosis , thalassemia , beta thalassemia , pathophysiology , medicine , anemia , biology , biochemistry
A bstract : To develop new treatments for β‐thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin ( Hamp ), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream. In mice, iron overload leads to overexpression of Hamp, while Hamp ‐knockout mice suffer from hemochromatosis. The aim of this study is to investigate Hamp in the mouse model of β‐thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.