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Different Effects of Adenosine A1 Agonist Ribavirin on Amphetamine‐Induced Total Locomotor and Stereotypic Activities in Rats
Author(s) -
JANAĆ BRANKA,
PEŠIĆ VESNA,
PEKOVIĆ SANJA,
RAKIĆ LJUBISAV,
STOJILJKOVIĆ MIRJANA
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1342.048
Subject(s) - licking , amphetamine , ribavirin , chemistry , locomotor activity , sniffing , agonist , pharmacology , endocrinology , medicine , psychology , neuroscience , biochemistry , receptor , genotype , dopamine , gene
A bstract : Pretreatment with a single dose of ribavirin (10, 20, and 30 mg/kg b.w. i.p.) decreased amphetamine (1.5 mg/kg b.w. i.p.)‐induced total locomotor activity (distance traveled) compared to amphetamine alone, but the most significant effect was observed with 30 mg/kg dose. In contrast, total stereotypic activities (such as sniffing, self‐grooming, licking, and head weaving) of these animals were unchanged. These findings demonstrate the ability of ribavirin to modulate in a different way central regulation of locomotor and stereotypic activities that in the future could have a practical application in target therapy of some movement disorders.