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Combination of Nucleoside Analogues Tiazofurin and Ribavirin Downregulates Experimental Autoimmune Encephalomyelitis
Author(s) -
LAVRNJA IRENA,
STOJKOV DANIJELA,
PEKOVIĆ SANJA,
ŠUBAŠIĆ SANJA,
MOSTARICASTOJKOVIĆ MARIJA,
STOŠICGRUJIČIĆ STANISLAVA,
NEDELJKOVIĆ NADEŽDA,
MEDIĆMIJAČEVIĆ LJUBICA,
RAKIĆ LJUBISAV,
STOJILJKOVIĆ MIRJANA
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1342.047
Subject(s) - ribavirin , experimental autoimmune encephalomyelitis , multiple sclerosis , medicine , adjuvant , nucleoside , autoimmune disease , immunology , encephalomyelitis , pharmacology , virus , biology , antibody , biochemistry , hepatitis c virus
A bstract : The effect of combined treatment with ribavirin and tiazofurin on the development of experimental autoimmune encephalomyelitis, the best characterized animal model for human autoimmune disease multiple sclerosis, was investigated. The disease was induced in highly susceptible Dark Agouti rats with spinal cord homogenate in complete Freund's adjuvant. Although ribavirin or tiazofurin alone reduced the clinical and histopathological signs of experimental autoimmune encephalomyelitis, the combination of drugs achieved the same effect with significantly lower doses.