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Antioxidant Enzyme Activity in Rat Hippocampus after Chronic and Acute Stress Exposure
Author(s) -
STOJILJKOVIĆ VESNA,
TODOROVIĆ ANA,
KASAPOVIĆ JELENA,
PEJIĆ SNEŽANA,
PAJOVIĆ SNEŽANA B.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1342.042
Subject(s) - superoxide dismutase , antioxidant , oxidative stress , catalase , chronic stress , hippocampus , chemistry , hippocampal formation , pathological , endocrinology , medicine , dismutase , biochemistry
A bstract : Chronic exposure to stress alters the prooxidant‐antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress‐induced injury, we examined the effects of two types of acute stress, as well as combined effects of chronic and acute stress on manganese‐superoxide dismutase, copper, zinc‐superoxide dismutase, and catalase activities in rat brain hippocampus. Our results show that chronic stress induces an increase in oxidative enzyme activities and that adaptation to chronic stress might alter hippocampal antioxidant mechanisms' response to acute stress.