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Differences in Antioxidative Response of Rat Hippocampus and Cortex after Exposure to Clinical Dose of γ‐Rays
Author(s) -
TODOROVIĆ ANA,
KASAPOVIĆ JELENA,
PEJIĆ SNEŽANA,
STOJILJKOVIĆ VESNA,
PAJOVIĆ SNEŽANA B.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1342.041
Subject(s) - hippocampus , neuroscience , chemistry , cortex (anatomy) , biology
A bstract : Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area‐dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1 h and 24 h after exposure to 2 Gy of γ‐rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region.