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Mitochondrial Superoxide Production and MnSOD Activity after Exposure to Agonist and Antagonists of Ionotropic Glutamate Receptors in Hippocampus
Author(s) -
RADENOVIĆ LIDIJA,
SELAKOVIĆ VESNA,
KARTELIJA GORDANA
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1342.039
Subject(s) - kainate receptor , cnqx , ampa receptor , ionotropic effect , neuroprotection , glutamate receptor , superoxide , chemistry , agonist , hippocampus , nmda receptor , receptor , ionotropic glutamate receptor , kainic acid , excitotoxicity , pharmacology , neuroscience , biology , biochemistry , enzyme
A bstract : Competitive glutamate receptor antagonists APV and CNQX were injected with kainate unilaterally into CA3 region of the rat hippocampus. They both expressed sufficient neuroprotection in the sense of decreasing superoxide production and increasing MnSOD levels, but with differential effect in mechanisms and time dynamics. Our findings suggest that NMDA and AMPA/kainate receptors are differentially involved in superoxide production, and they also impose different neuroprotective effects on the induction of MnSOD activity in hippocampus.