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A New Noninvasive Test to Detect Mitochondrial Dysfunction of Skeletal Muscles in Progressive Supranuclear Palsy
Author(s) -
CHANG YUNGYEE,
LEE CHIANGHSUAN,
LAN MINYU,
WU HSIUSHAN,
CHANG CHIUNGCHIH,
LIU JIASHOU
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1338.046
Subject(s) - progressive supranuclear palsy , medicine , neuroscience , physical medicine and rehabilitation , pathology , biology , disease
A bstract : We present usage of technetium‐99m methoxyisobutyl isonitrile ( 99m Tc‐sestamibi) single photon emission computed tomography (SPECT) as a novel noninvasive method to evaluate muscular mitochondrial function in patients with progressive supranuclear palsy (PSP). 99m Tc‐sestamibi SPECT revealed a statistically significant decrease in radionucleotide uptake in the quadriceps in PSP patients as compared with other neurodegenerative parkinsonism ( P < 0.05 ) or control group ( P < 0.05 ). This study demonstrates a remarkable deficit of skeletal muscle bioenergetics in patients with PSP. Our findings suggest a distinctive role of mitochondrial dysfunction in the pathogenesis of PSP. Furthermore, 99m Tc‐sestamibi SPECT provides a relatively simple, inexpensive, and noninvasive modality in further assessment of mitochondrial function and bioenergetic features in various muscular disorders.