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Potential Mechanism of Blood Vessel Protection by Resveratrol, a Component of Red Wine
Author(s) -
HUANG HUEIMEI,
LIANG YUCHIH,
CHENG TZUHURNG,
CHEN CHENGHEIEN,
JUAN SHUHUI
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1338.032
Subject(s) - resveratrol , neuroprotection , chemistry , mapk/erk pathway , antioxidant , pharmacology , protein kinase a , luciferase , mechanism of action , kinase , microbiology and biotechnology , biochemistry , biology , in vitro , gene , transfection
A bstract : Resveratrol‐mediated heme oxgenase‐1 (HO‐1) induction has been shown to occur in primary neuronal cultures and has been implicated as having potential neuroprotective action. Further, antioxidant properties of resveratrol have been reported to protect against coronary heart disease. We attempted to examine the HO‐1 inducing potency of resveratrol and the regulatory mechanism of its induction in rat aortic smooth muscle cells (RASMC). We showed that resveratrol‐induced HO‐1 expression was concentration‐ and time‐dependent. The level of HO‐1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor‐kappa B (NF‐κB) inhibitors, but not by mitogen‐activated protein kinase (MAPK) inhibitors. Deletion of NF‐κB binding sites in the promoter region strongly reduced luciferase activity. Collectively, we suggest that resveratrol‐mediated HO‐1 expression occurs, at least in part, through the NF‐κB pathway.