A Second‐Generation Genome Screen for Linkage to Type 1 Diabetes in a Bedouin Arab Family | Zendy

BABU SUNANDA R. | Zendy; CONANT GAVIN C. | Zendy; ELLER ELISE | Zendy; ROBERTS CHRISTINE M. | Zendy; GOWAN KATHERINE | Zendy; EISENBARTH GEORGE S. | Zendy; FAIN PAMELA R. | Zendy; VARDI PNINA | Zendy

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A Second‐Generation Genome Screen for Linkage to Type 1 Diabetes in a Bedouin Arab Family

Author(s) -

BABU SUNANDA R.,

CONANT GAVIN C.,

ELLER ELISE,

ROBERTS CHRISTINE M.,

GOWAN KATHERINE,

EISENBARTH GEORGE S.,

FAIN PAMELA R.,

VARDI PNINA

Publication year - 2004

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1337.026

Subject(s) - genetic linkage , linkage (software) , genetics , locus (genetics) , genome , offspring , lod score , biology , gene , chromosome , gene mapping , pregnancy

A bstract : IDDM17 on chromosome 10 was identified in an initial genome screen of 13 members (10 affected) of a large Bedouin Arab family that had 19 relatives affected with type 1 diabetes. Two more children have now been diagnosed with the disease. A second genome screen with 45 members (17 affected members, spouses, and offspring; 382 markers) was performed. A parallel version of Genehunter was used for parametric and nonparametric linkage analyses. The nonparametric linkage analysis (NPL) confirmed the IDDM17 locus (NPL = 3.79; P = 0.001 ) with a prominent LOD (logarithm of the odds = 2.38) peak. These results demonstrate the strong potential of genetically homogenous, extended families for mapping genes that contribute to a complex disease.

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