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A Second‐Generation Genome Screen for Linkage to Type 1 Diabetes in a Bedouin Arab Family
Author(s) -
BABU SUNANDA R.,
CONANT GAVIN C.,
ELLER ELISE,
ROBERTS CHRISTINE M.,
GOWAN KATHERINE,
EISENBARTH GEORGE S.,
FAIN PAMELA R.,
VARDI PNINA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1337.026
Subject(s) - genetic linkage , linkage (software) , genetics , locus (genetics) , genome , offspring , lod score , biology , gene , chromosome , gene mapping , pregnancy
A bstract : IDDM17 on chromosome 10 was identified in an initial genome screen of 13 members (10 affected) of a large Bedouin Arab family that had 19 relatives affected with type 1 diabetes. Two more children have now been diagnosed with the disease. A second genome screen with 45 members (17 affected members, spouses, and offspring; 382 markers) was performed. A parallel version of Genehunter was used for parametric and nonparametric linkage analyses. The nonparametric linkage analysis (NPL) confirmed the IDDM17 locus (NPL = 3.79; P = 0.001 ) with a prominent LOD (logarithm of the odds = 2.38) peak. These results demonstrate the strong potential of genetically homogenous, extended families for mapping genes that contribute to a complex disease.