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Prevalence of Diabetes‐Associated Autoantibodies in Schoolchildren: The Karlsburg Type 1 Diabetes Risk Study
Author(s) -
SCHLOSSER MICHAEL,
STREBELOW MARTINA,
RJASANOWSKI ILONA,
KERNER WOLFGANG,
WASSMUTH RALF,
ZIEGLER MANFRED
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1337.017
Subject(s) - medicine , autoantibody , type 1 diabetes , diabetes mellitus , population , glutamate decarboxylase , proband , insulin , endocrinology , immunology , antibody , environmental health , biology , biochemistry , enzyme , gene , mutation
A bstract : This study attempts to assess the prevalence of diabetes‐associated autoantibodies in a general population in the northeastern part of Germany, with emphasis on autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA‐2A), and insulin (IAA) by radioassays ≥ 98th percentile, and AAbs binding on pancreatic sections (ICA) by immunofluorescence ≥ 10 Juvenile Diabetes Foundation units. From a total of 11,840 schoolchildren tested for all four AAbs, 821 (6.9%) children were positive for single AAbs, whereas 83 (0.7%) had multiple AAbs. If the primary screening were performed by testing GADA/IA‐2A/IAA, 94% of probands with single AAbs and all with multiple AAbs would be identified. The combinations of GADA/IA‐2A, GADA/IAA, and IA‐2A/IAA would identify 97.6, 98.8, and 85.5% of probands with multiple AAbs, respectively. Thus, combined AAb screening in the general population identifies those probands at risk for diabetes.