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Preproinsulin‐Specific CD8 + T Cells Secrete IFNγ in Human Type 1 Diabetes
Author(s) -
RATHMANN SILVIA,
RAJASALU TARVO,
ROSINGER SILKE,
SCHLOSSER MICHAEL,
EIERMANN THOMAS,
BOEHM BERNHARD O.,
DURINOVICBELLÓ IVANA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1337.004
Subject(s) - cytotoxic t cell , secretion , cd8 , epitope , cytokine , type 1 diabetes , biology , t cell , immunology , chemistry , in vitro , microbiology and biotechnology , immune system , antigen , diabetes mellitus , endocrinology , biochemistry
A bstract : In animal models autoreactive CD8 + T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8 + T cell‐mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8 + T cells contribute to a strong IFNγ reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development.