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Genetic Basis of Endometriosis
Author(s) -
BISCHOFF FARIDEH,
SIMPSON JOE LEIGH
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1335.030
Subject(s) - multifactorial inheritance , endometriosis , inheritance (genetic algorithm) , candidate gene , biology , disease , missing heritability problem , heritability , identification (biology) , genetics , gene , genome wide association study , bioinformatics , computational biology , medicine , genetic variants , single nucleotide polymorphism , pathology , genotype , botany
A bstract : Endometriosis is a complex gynecologic disorder that has long been recognized as showing heritable tendencies, with recurrence risks of 5‐7% for first‐degree relatives. Familial and epidemiologic studies support that this disease is a genetic disorder of polygenic/multifactorial inheritance. The current investigational challenge is to determine the number and location of causative genes. Recent advances in molecular technology make identification and elucidation of these genes now possible. In this review, we update previous communications in which we also reviewed heritability studies supporting polygenic/multifactorial inheritance, discuss the scientific basis of genomewide strategies for identifying causative genes, and identify potential candidate genes.