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Endometrial Evaluation in Superovulation Programs: Relationship with Successful Outcome
Author(s) -
TROPEA ANNA,
MICELI FIORELLA,
MINICI FRANCESCA,
ORLANDO MARIATERESA,
LAMANNA GIUSEPPINA,
GANGALE MARIAFRANCESCA,
CATINO STEFANIA,
LANZONE ANTONIO,
APA ROSANNA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1335.023
Subject(s) - endometrium , implantation failure , ovulation , gynecology , medicine , pregnancy rate , ovulation induction , pregnancy , embryo , andrology , embryo transfer , obstetrics , infertility , hormone , biology , genetics , microbiology and biotechnology
A bstract : It is well known that an adequate endometrial receptivity is required for successful implantation in both natural and assisted reproductive cycles. In particular, a brief “implantation window”, during which endometrium undergoes anatomical and molecular changes necessary for embryo implantation, has been observed. The hormonal treatment applied to induce ovulation seems to be able to modify the normal development of the prenidatory endometrium, with possible negative effect on the implantation rate. For this reason, several attempts have been made to identify specific markers of endometrial receptivity, useful for predicting implantation outcome in clinical practice. Even if different histological, immunohistochemical, and ultrasonographic parameters are studied, none unfortunately has been univocally shown to be predictive of pregnancy outcome. Therefore, the evaluation of endometrial receptivity remains a challenge in clinical practice.