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Umbilical Cord Blood‐Derived Stem Cells and Brain Repair
Author(s) -
SANBERG PAUL R.,
WILLING ALISON E.,
GARBUZOVADAVIS SVITLANA,
SAPORTA SAMUEL,
LIU GUOQING,
SANBERG CYNDY DAVIS,
BICKFORD PAULA C.,
KLASKO STEPHEN K.,
ELBADRI NAGWA S.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1334.008
Subject(s) - stem cell , medicine , umbilical cord , neural stem cell , cord blood , population , adult stem cell , stem cell therapy , neurotrophic factors , bone marrow stem cell , transplantation , cell therapy , immunology , bone marrow , embryonic stem cell , surgery , biology , microbiology and biotechnology , biochemistry , receptor , environmental health , gene
A bstract : Human umbilical cord blood (HUCB) is now considered a valuable source for stem cell‐based therapies. HUCB cells are enriched for stem cells that have the potential to initiate and maintain tissue repair. This potential is especially attractive in neural diseases for which no current cure is available. Furthermore, HUCB cells are easily available and less immunogenic compared to other sources for stem cell therapy such as bone marrow. Accordingly, the number of cord blood transplants has doubled in the last year alone, especially in the pediatric population. The therapeutic potential of HUCB cells may be attributed to inherent ability of stem cell populations to replace damaged tissues. Alternatively, various cell types within the graft may promote neural repair by delivering neural protection and secretion of neurotrophic factors. In this review, we evaluate the preclinical studies in which HUCB was applied for treatment of neurodegenerative diseases and for traumatic and ischemic brain damage. We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome.