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Effects of Modified Low‐Density Lipoproteins on Human Retinal Pericyte Survival
Author(s) -
SONG WEIWEI,
BARTH JEREMY L.,
LU KANGMO,
YU YONGXIN,
HUANG YAN,
GITTINGER CYNTHIA K.,
ARGRAVES W SCOTT,
LYONS TIMOTHY J.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1333.045
Subject(s) - pericyte , retinal , diabetic retinopathy , apoptosis , chemistry , retina , dna fragmentation , low density lipoprotein , cytotoxicity , medicine , endocrinology , diabetes mellitus , biology , programmed cell death , biochemistry , endothelial stem cell , cholesterol , in vitro , neuroscience
A bstract : According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low‐density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G‐LDL) and heavily oxidized glycated LDL (HOG‐LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG‐LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG‐LDL could be implicated in the development of diabetic retinopathy.