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Simple Noninvasive Measurement of Skin Autofluorescence
Author(s) -
MEERWALDT ROBBERT,
LINKS THERA,
GRAAFF REINDERT,
THORPE SUZANNNE R.,
BAYNES JOHN W.,
HARTOG JASPER,
GANS REINOLD,
SMIT ANDRIES
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1333.036
Subject(s) - autofluorescence , medicine , diabetes mellitus , glycation , pathogenesis , glycemic , advanced glycation end product , pathology , endocrinology , fluorescence , physics , quantum mechanics
A bstract : Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. Several studies indicate that AGE accumulation in tissue may reflect the cumulative effect of hyperglycemia and oxidative stress over many years. Simple quantitation of AGE accumulation in tissue could provide a tool for assessing the risk of long‐term complications. Because several AGEs exhibit autofluorescence, we developed a noninvasive autofluorescence reader (AFR). Skin autofluorescence measured with the AFR correlates with collagen‐linked fluorescence and specific skin AGE levels from skin biopsy samples. Furthermore, skin autofluorescence correlates with long‐term glycemic control and renal function, and preliminary results show correlations with the presence of long‐term complications in diabetes. The AFR may be useful as a clinical tool for rapid assessment of risk for AGE‐related long‐term complications in diabetes and in other conditions associated with AGE accumulation.