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Effects of Vitamin E Depletion/Repletion on Biomarkers of Oxidative Stress in Healthy Aging
Author(s) -
WINKLHOFERROOB BRIGITTE M.,
MEINITZER ANDREAS,
MARITSCHNEGG MICHAELA,
ROOB JOHANNES M.,
KHOSCHSORUR GHOLAMALI,
RIBALTA JOSEP,
SUNDL ISABELLA,
WUGA SANDRA,
WONISCH WILLIBALD,
TIRAN BEATE,
ROCK EDMOND
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1331.045
Subject(s) - oxidative stress , lipid peroxidation , vitamin e , ex vivo , antioxidant , vitamin c , oxidative phosphorylation , endocrinology , chemistry , medicine , vitamin , oxidative damage , biochemistry , in vitro
A bstract : The effects on ex vivo LDL resistance to oxidation and biomarkers of in vivo oxidative stress in response to 3‐month dietary vitamin E restriction to 25% of recommended intake and 2‐month unrestricted dietary intake and supplementation with 800 IU/d were studied in 100 healthy, nonsmoking 20‐75‐year‐old volunteers. Significant changes in vitamin E status were associated with decreases and increases, respectively, in LDL resistance to oxidation in the depletion and supplementation period and with decreases in lipid peroxidation and oxidative DNA modification in the supplementation period. Healthy aging was not associated with enhanced susceptibility to oxidation in the depletion period.