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The Transcriptional Signature of Vitamin E
Author(s) -
JOHNSON AMY,
MANOR DANNY
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1331.037
Subject(s) - gene expression , gene , transcription (linguistics) , rna , regulation of gene expression , transcriptional regulation , microbiology and biotechnology , vitamin e , transcriptome , biology , genetics , biochemistry , antioxidant , linguistics , philosophy
A bstract : To investigate the ability of RRR‐α‐tocopherol to regulate gene expression, we interrogated RNA samples from treated cultured cells with Affymetrix oligonucleutodie arrays. We find that vitamin E potently regulates the expression of ca. 230 genes, functioning in metabolism, cell‐cycle progression, and transcriptional regulation.