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Structure‐Function Relationship in the Tocopherol Transfer Protein
Author(s) -
MORLEY S,
PANAGABKO C,
STOCKER A,
ATKINSON J,
MANOR D
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1331.035
Subject(s) - chemistry , tocopherol , mutagenesis , site directed mutagenesis , amino acid residue , amino acid , function (biology) , biochemistry , mechanism of action , mechanism (biology) , biophysics , antioxidant , microbiology and biotechnology , biology , peptide sequence , mutation , in vitro , vitamin e , mutant , gene , philosophy , epistemology
A bstract : The role of specific amino acid residues in mediating the biochemical functions of tocopherol transfer protein (TTP) was investigated using site‐directed mutagenesis and functional assays. These findings further current understanding of TTP mechanism of action and its role in human health.