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GATA‐1: Friends, Brothers, and Coworkers
Author(s) -
MORCEAU FRANCK,
SCHNEKENBURGER MICHAEL,
DICATO MARIO,
DIEDERICH MARC
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1329.064
Subject(s) - gata2 , zinc finger , gata1 , gata transcription factor , transcription factor , gata4 , haematopoiesis , biology , gene , genetics , microbiology and biotechnology , transcription (linguistics) , dna binding protein , dna , gene expression , promoter , stem cell , linguistics , philosophy
A bstract : GATA‐1 is the founding member of the GATA family of transcription factors. GATA‐1 and GATA family member GATA‐2 are expressed in erythroid and megakaryocytic lineages, in which they play a crucial role in cell maturation and differentiation. GATA‐1 regulates the transcription of many specific and nonspecific erythroid genes by binding to DNA at the consensus sequence WGATAR, which is recognized by all of the GATA family of transcription factors. However, it was identified in eosinophilic cells and also in Sertoli cells in testis. Its activity depends on close cooperation with a functional network of cofactors, among them Friend of GATA, PU.1, and CBP/p300. The GATA‐1 protein structure has been well described and includes two zinc fingers that are directly involved in the interaction with DNA and other proteins in vivo . GATA‐1 mutations in the zinc fingers can cause deregulation of required interactions and lead to severe dysfunction in the hematopoietic system.