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Linkage Mapping of the [Pro 2 ]Somatostatin‐14 Gene in Zebrafish: Evolutionary Perspectives
Author(s) -
TOSTIVINT HERVÉ,
JOLY LUCILLE,
LIHRMANN ISABELLE,
CONLON J MICHAEL,
EKKER MARC,
VAUDRY HUBERT
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.098
Subject(s) - zebrafish , gene , biology , genetics , locus (genetics) , genetic linkage , genome , gene mapping , chromosome
A bstract : Radiation hybrid mapping assigned the zebrafish [Pro 2 ]somatostatin‐14 (also termed somatostatin 2; SS2) gene to linkage group 23 of the zebrafish genome, close to the marker nadl1.2. Comparative genomic analysis revealed conserved syntenies of the SS2 gene locus with part of the human 1p36 region, where the cortistatin gene is located. This observation strongly suggests that the SS2 gene in nonmammalian species and the cortistatin gene in mammals are orthologous.