Premium
Pleiotropic Action of Insulin‐like Peptides of Mollusk, Anodonta cygnea
Author(s) -
SHIPILOV V.N,
SHPAKOV A O,
RUSAKOV YU I
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.091
Subject(s) - action (physics) , insulin , chemistry , pharmacology , biology , endocrinology , physics , quantum mechanics
A bstract : Insulin‐related peptides (IRPs) from ganglions of mollusk, Anodonta cygnea , were purified and characterized (IRP1‐IRP13) using insulin and insulin‐like growth factor‐I (IGF‐I) radioreceptor test systems. The IRPs were able to bind to insulin and IGF‐I receptors. Dose‐dependent curve slopes indicated that most IRPs bind with higher affinity to IGF‐I receptors than to insulin receptors. The IRP regulatory action on the activity of the adenylyl cyclase signal system showed that these peptides stimulated adenylyl cyclase and GTP‐binding activity of G‐proteins to the same extent as insulin and IGF‐I. The data obtained suggest polyfunctional IRP action that apparently is determined by the molecular structure of individual isoforms.