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Unusual Genomic Structure: Melanocortin Receptors in Fugu
Author(s) -
SCHIÖTH HELGI B.,
HAITINA TATJANA,
FRIDMANIS DAVIDS,
KLOVINS JANIS
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.090
Subject(s) - fugu , melanocortin , melanocortin 3 receptor , receptor , g protein coupled receptor , biology , computational biology , genetics , gene , melanocortin receptor , zebrafish
A bstract : The melanocortin (MC) receptors are found in five subtypes in mammals and chicken, while recent studies have shown that the Fugu ( Takifugu rubripes ) genome has only four MC receptors and the zebrafish genome has six subtypes. The MC3 receptor seems to be missing from the two closely related pufferfishes, Fugu and Tetraodon ( Tetraodon nigroviridis ). The MC2 and MC5 receptors in the pufferfish have introns. Moreover, these two receptors are found in a tandem that is remarkably conserved in several vertebrate species. Here, we speculate about the genomic origin of the MC receptors.