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Neurotoxicity of Polychlorinated Biphenyls (PCBs) by Disturbance of Thyroid Hormone‐Regulated Genes
Author(s) -
ROELENS S.A,
BECK V,
AERTS G,
CLERENS S.,
BERGH G,
ARCKENS L,
DARRAS V M,
DER GEYTEN S.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.088
Subject(s) - neurotoxicity , gene , hormone , thyroid , toxicity , endocrinology , medicine , congener , gene expression , biology , chemistry , environmental chemistry , biochemistry
A bstract : PCBs are known as neurotoxic compounds. Part of this neurotoxicity could be due to an alteration of the expression of TH‐regulated genes in brain. To identify such genes, brain protein extracts of hypo‐ and hyperthyroid as well as PCB‐treated embryos were compared by fluorescent 2D‐DIGE. In total, we observed 109 differentially expressed proteins, of which 17 differed with both PCB and hypo‐ or hyperthyroid treatment. It was found that the interaction of PCBs with the expression of TH‐regulated genes is congener‐specific and that both hyperthyroidism‐ and hypothyroidism‐related effects occur.