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Involvement of Adenylyl Cyclase Signaling Mechanism in Insulin and IGF‐I Coregulation of Fundamental Cell Processes
Author(s) -
PERTSEVA M.N
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.081
Subject(s) - adenylyl cyclase , mechanism (biology) , insulin , microbiology and biotechnology , signal transduction , chemistry , adcy9 , medicine , endocrinology , biology , physics , quantum mechanics
A bstract : The discovery of the adenylyl cyclase signaling mechanism (ACSM) of insulin and related peptides allows for advancing the hypothesis of its participation in regulatory action on cell growth, apoptosis, and metabolism. The following evidences were obtained: (1) The order of efficiency of insulin and IGF‐I growth‐promoting action and their antiapoptotic effect coincides with that of the peptide‐activating action on AC. (2) The growth‐promoting and antiapoptotic effects of insulin and IGF‐I are distinctly reproduced by cAMP. (3) The anabolic effects of insulin and IGF‐I activation on glycogen synthesis and the pentosophosphate pathway are inhibited by cAMP.