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Structure of Msj‐1 Gene: A Comparative Analysis
Author(s) -
MECCARIELLO R.,
TEDESCHI G,
MONSURRÒ M R,
CHIANESE R.,
COBELLIS G,
PIERANTONI R.,
FASANO S
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.075
Subject(s) - gene , mathematics , coding (social sciences) , computational biology , genetics , biology , statistics
A bstract :Msj‐1 gene encodes a DnaJ protein highly expressed in spermatids and spermatozoa of both rodents and amphibians. We isolated and characterized the msj‐1 gene in mice. A bioinformatic approach was then used to predict the putative promoter region, chromosomal localization, and its presence in the human genome. The analysis of msj‐1 genomic sequence revealed that msj‐1 is an intronless gene. Interestingly, two regions (A and B, separated by 10,682 bp) on human chromosome 2 having respectively 78% and 77% nucleotide identity with the murine msj‐1 coding region were identified. This suggests the existence of an msj‐1 ‐like gene also in humans.