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Pufferfish and Zebrafish Have Five Distinct NPY Receptor Subtypes, but Have Lost Appetite Receptors Y1 and Y5
Author(s) -
LARSSON TOMAS A.,
OLSSON FRIDA,
SUNDSTRÖM GÖREL,
BRENNER SYDNEY,
VENKATESH BYRAPPA,
LARHAMMAR DAN
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.066
Subject(s) - receptor , appetite , zebrafish , neuropeptide y receptor , biology , endocrinology , medicine , genetics , neuropeptide , gene
A bstract : The two neuropeptide Y (NPY) receptors Y1 and Y5 stimulate feeding in mammals, but are missing in the euteleosts, zebrafish and pufferfish ( Takifugu rubripes ). Both species have five other subtypes called Y2, Y7, Ya, Yb, and Yc. RT‐PCR studies in pufferfish show that all five are expressed in the brain and may mediate NPY effects on feeding. Y2, Ya, and Yb are also broadly expressed in peripheral organs. These results reveal interesting differences in the NPY system of teleosts and mammals that may have arisen in the genetic turmoil involving the basal ray‐fin fish tetraploidization.