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Development of the Circadian Melatonin Rhythm and Its Responsiveness to PACAP in the Embryonic Chicken Pineal Gland
Author(s) -
FALUHELYI N,
REGLODI D,
CSERNUS V
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.048
Subject(s) - melatonin , endocrinology , medicine , circadian rhythm , pineal gland , embryonic stem cell , embryogenesis , biology , microbiology and biotechnology , secretion , signal transduction , intracellular , embryo , biochemistry , gene
A bstract : The embryonic development of the circadian melatonin (MT) rhythm and the responsiveness of embryonic MT secretion to pituitary adenylate cyclase‐activating polypeptide (PACAP) were investigated. Using dynamic in vitro bioassays, we showed the following: (1) The circadian clock and/or the intracellular signal transduction pathways connecting the clock to the MT synthesizing apparatus appear between days 16 and 18 (E16‐18) of embryonic development. Lack of periodical environmental stimuli can lead to a delay in this maturation. (2) Exposure of the embryonic chicken pineal gland to PACAP induces a transitory increase in MT secretion and (3) a transitory increase in cyclic AMP efflux at or before day E13 in vitro .