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Adipokinetic Hormone and the Immune Responses of Locusts to Infection
Author(s) -
GOLDSWORTHY G J,
OPOKUWARE K,
MULLEN L M
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.013
Subject(s) - adipokinetic hormone , metarhizium anisopliae , metarhizium , locust , hemolymph , prophenoloxidase , microbiology and biotechnology , biology , entomopathogenic fungus , bacteria , antimicrobial , escherichia coli , immune system , innate immune system , botany , biochemistry , immunology , biological pest control , beauveria bassiana , larva , fat body , genetics , gene
A bstract : Injections of Bacillus , or of blastospores from the entomopathogenic fungus, Metarhizium anisopliae , activate the prophenoloxidase (PPO) cascade, and coinjection of adipokinetic hormone‐I (AKH) enhances and prolongs these responses. When injected concurrently with an immunizing dose of live bacteria, AKH suppresses the appearance of antimicrobial activity and, after a short delay, increases the growth of bacteria within the hemocoel. Injections of live Escherichia coli or Pseudomonas aeruginosa into locusts fail to activate PPO in the hemolymph, even when coinjected with AKH. The coinjection of bacteria and hormone is rarely lethal to the locust. However, if locusts are injected with AKH when they are infected with Metarhizium , they die more rapidly than if no AKH is administered.