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Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals
Author(s) -
CHARTREL NICOLAS,
BRUZZONE FEDERICA,
DUJARDIN CYNTHIA,
LEPRINCE JEROME,
TOLLEMER HELENE,
ANOUAR YOUSSEF,
VALLARINO MAURO,
COSTENTIN JEAN,
VAUDRY HUBERT
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.009
Subject(s) - orexigenic , neuropeptide , medicine , biology , endocrinology , hypothalamus , neuropeptide y receptor , chemistry , microbiology and biotechnology , neuroscience , receptor
A bstract : In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro‐26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose‐dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.