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Trends in the Evolution of the Proenkephalin and Prodynorphin Genes in Gnathostomes
Author(s) -
KHALAP ASHLEY,
BAGROSKY BRIAN,
LECAUDE STEPHANIE,
YOUSON JOHN,
DANIELSON PHILLIP,
DORES ROBERT M.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1327.003
Subject(s) - proenkephalin , dynorphin , gene family , gene duplication , biology , gene , danio , genetics , zebrafish , opioid peptide , genome , opioid , receptor
A bstract : The opioid/orphanin gene family provides a model system for analyzing the outcomes of genome duplication events. Recent studies on the proenkephalin gene provide additional evidence that the organizational plan for this gene has been conserved throughout the extensive radiation of the gnathostome vertebrates. However, an analysis of the amino acid sequence of proenkephalin from the zebrafish, Danio rerio , suggests that novel forms of this opioid precursor may be evolving in teleosts. Analyses of sarcopterygian prodynorphin sequences revealed a proenkephalin signature in prodynorphin. Current studies on the opioid/orphanin gene family point to the duplication events that shaped this family occurring prior to the radiation of the gnathostomes.