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Toll‐Like Receptor Signaling and its Relevance to Intestinal Inflammation
Author(s) -
CARIO ELKE,
PODOLSKY DANIEL K.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1326.006
Subject(s) - inflammation , receptor , toll like receptor , signal transduction , toll , immunology , regeneration (biology) , mucosal inflammation , intestinal mucosa , biology , microbiology and biotechnology , medicine , innate immune system , immune system
This review discusses the current progress in the understanding of how commensal‐mediated activation of toll‐like receptors (TLRs) may be involved in the regulation of physiological and pathophysiological processes of the intestinal mucosa including tissue regeneration and inflammation. While regulation of TLRs and their downstream signaling mediators might be used to prevent and treat inflammatory bowel diseases, paradoxically, at this time, it remains uncertain whether this would be more effectively accomplished by enhancing or inhibiting these pathways.