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The Intestinal Microvasculature as a Therapeutic Target in Inflammatory Bowel Disease
Author(s) -
HATOUM OSSAMA A.,
HEIDEMANN JAN,
BINION DAVID G.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1326.003
Subject(s) - inflammatory bowel disease , ulcerative colitis , inflammation , angiogenesis , immune system , medicine , pathophysiology , crohn's disease , disease , immunology , inflammatory bowel diseases , colitis , pathology , cancer research
Chronic inflammation is a complex biologic process which involves immune as well as non‐immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.