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Antibody‐Mediated Antigen Sampling across Intestinal Epithelial Barriers
Author(s) -
BERIN M. CECILIA,
LI HONGXING,
SPERBER KIRK
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1326.002
Subject(s) - immune system , antigen , immunology , epithelium , gastrointestinal tract , biology , antibody , barrier function , gastrointestinal epithelium , intestinal epithelium , mucosal immunology , immunity , microbiology and biotechnology , biochemistry , genetics
The epithelium of the gastrointestinal tract is the interface between luminal contents and the mucosal immune system. It must function as a selective barrier to limit penetration of antigens yet keep the mucosal immune system “informed” for the purpose of generating oral tolerance responses to food antigens or commensal organisms and host defense responses against pathogens. Alterations in epithelial barrier function have been proposed to play a significant role in gastrointestinal disease. In this review, we will discuss mechanisms of regulation of epithelial barrier function, and we will focus on the emerging understanding of how secreted immunoglobulins play a role in antigen‐specific antigen sampling across the gastrointestinal epithelium.