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Neural Integrator Function in Murine CACNA1A Mutants
Author(s) -
STAHL JOHN S.,
JAMES ROBERT A.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1325.072
Subject(s) - integrator , cerebellum , neuroscience , mutant , function (biology) , master regulator , biology , phenotype , microbiology and biotechnology , genetics , physics , gene , quantum mechanics , voltage , transcription factor
A bstract : Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.