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Abnormal Eye Movements Predict Disability in MS: Two‐Year Follow‐Up
Author(s) -
DERWENSKUS JOY,
RUCKER JANET C.,
SERRA ALESSANDRO,
STAHL JOHN S.,
DOWNEY DEBORAH L.,
ADAMS NANCY L.,
LEIGH R.JOHN
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1325.058
Subject(s) - brainstem , eye movement , medicine , cerebellum , audiology , physical medicine and rehabilitation , ophthalmology
A bstract : We conducted a two‐year follow‐up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly ( p < .001 ) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.