Premium
Saccadic Analysis for Early Identification of Neurological Involvement in Gaucher Disease
Author(s) -
ACCARDO A.P.,
PENSIERO S,
PERISSUTTI P
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1325.054
Subject(s) - saccadic masking , identification (biology) , disease , medicine , pediatrics , neuroscience , psychology , pathology , eye movement , biology , botany
A bstract : The early identification of a neurological involvement in Gaucher's Disease (GD) is essential for a correct dosage of the enzymatic therapy. The saccadic eye movement characteristics of 15 patients affected by the non‐neurological GD form show normal peak velocity values and some slight alterations of the velocity profiles present in more than 70% of the recorded eye movements in four cases; two of them later developed epilepsy. This fact supports the hypothesis that the presence of alterations in the velocity profile of the most part of saccadic movements is an index of initial neurological involvement. Further evaluations are necessary in order to understand if an increase of therapy dose should be used in all the subjects presenting such saccadic alterations.