Premium
Antioxidant Betalains from Cactus Pear ( Opuntia ficus‐indica ) Inhibit Endothelial ICAM‐1 Expression
Author(s) -
GENTILE C,
TESORIERE L,
ALLEGRA M,
LIVREA M A,
D'ALESSIO P
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1322.057
Subject(s) - pear , oxidative stress , antioxidant , chemistry , inflammation , biochemistry , free radical scavenger , endothelium , biology , traditional medicine , botany , immunology , medicine , endocrinology
A bstract : It has been suggested that some pigments would have antioxidant properties and that their presence in dietary constituents would contribute to reduce the risk of oxidative stress‐correlated diseases. Among others, inflammatory response depends on redox status and may implicate oxidative stress. Vascular endothelial cells are a direct target of oxidative stress in inflammation. We have tested the impact of the free radical scavenger and antioxidant properties of betalains from the prickle pear in an in vitro model of endothelial cells. Here we show the capacity of betalains to protect endothelium from cytokine‐induced redox state alteration, through ICAM‐1 inhibition.