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Targeting Multiple Myeloma Cells and Their Bone Marrow Microenvironment
Author(s) -
PAGNUCCO GUIDO,
CARDINALE GIOVANNI,
GERVASI FRANCESCO
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1322.047
Subject(s) - bone marrow , homing (biology) , multiple myeloma , cancer research , angiogenesis , stroma , stromal cell , medicine , tumor microenvironment , bortezomib , pathogenesis , bone disease , thalidomide , immunology , pathology , biology , tumor cells , osteoporosis , ecology , immunohistochemistry
A bstract : Although multiple myeloma (MM) is sensitive to chemotherapy and radiation therapy, long‐term disease‐free survival is rare, and MM remains incurable despite conventional and high‐dose therapies. Direct (cell‐cell contact) and soluble (via cytokines) forms of interactions between MM cells and bone marrow stroma regulate growth, survival, and homing of MM cells. These interactions also play a critical role in angiogenesis and in myeloma bone disease. In recent years, several studies have established the biologic significance of cytokines in MM pathogenesis and delineated signaling cascades mediating their effects, providing the framework for related novel therapies targeting not only the MM cell, but also the bone marrow microenvironment.