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Expression of IAPs and Alternative Splice Variants in Hepatocellular Carcinoma Tissues and Cells
Author(s) -
NOTARBARTOLO MONICA,
CERVELLO MELCHIORRE,
GIANNITRAPANI LYDIA,
MELI MARIA,
POMA PAOLA,
DUSONCHET LUISA,
MONTALTO GIUSEPPE,
D'ALESSANDRO NATALE
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1322.033
Subject(s) - xiap , hepatocellular carcinoma , survivin , inhibitor of apoptosis , cancer research , splice , alternative splicing , biology , apoptosis , medicine , gene , genetics , caspase , gene isoform , programmed cell death
A bstract : IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.