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Apoptosis Signaling in Tumor Therapy
Author(s) -
FULDA SIMONE,
DEBATIN KLAUSMICHAEL
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1322.016
Subject(s) - apoptosis , programmed cell death , suicide gene , cancer research , cancer , cancer cell , immunotherapy , cytotoxic t cell , cell growth , immunology , genetic enhancement , biology , medicine , gene , in vitro , biochemistry , genetics
A bstract : Apoptosis, the cell's intrinsic program to death, plays a central role in physiological growth control and regulation of tissue homeostasis. Tipping the balance between cell death and proliferation in favor of cell survival may result in tumor formation. Also, killing of cancer cells by cytotoxic therapies currently used for treatment of cancer, for example, chemotherapy, γ‐irradiation, immunotherapy, or suicide gene therapy, largely depends on activation of apoptosis programs in cancer cells. Accordingly, failure to undergo apoptosis in response to anticancer therapy may result in cancer resistance. Further insights into the mechanisms regulating apoptosis in response to anticancer therapy and how cancer cells evade cell death may provide novel opportunities for drug development.