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Extracellular Ribonucleic Acids of Human Milk
Author(s) -
SEMENOV DMITRY V.,
KULIGINA ELENA V.,
SHEVYRINA OLESYA N.,
RICHTER VLADIMIR A.,
VLASSOV VALENTIN V.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1318.029
Subject(s) - extracellular , chemistry , rna , biochemistry , gene
A bstract : Human milk has been shown to contain heterogeneous oligoribonucleotides varying in size from dimers to 100 mers. The sets of long oligonucleotides in milk samples from different donors and from different stages of lactation have some conservative elements. Sequences of some RNA oligonucleotides correspond to the 3′‐part of 5.8S human ribosomal RNA and to 3′‐parts of tRNA Val and tRNA Tyr . Primary structures of other oligo‐RNAs are homologous to fragments of human 18S and 28S rRNAs. Concentration of RNA in milk samples tends to decrease with lactation development. The change of RNA concentration and the low concentration of DNA in milk plasma suggest that the source of RNA in human milk may be active secretion of RNA by mammary gland cells.