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A Role for Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in Detrusor Hyperreflexia after Spinal Cord Injury (SCI)
Author(s) -
ZVARA PETER,
BRAAS KAREN M.,
MAY VICTOR,
VIZZARD MARGARET A.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.092
Subject(s) - spinal cord injury , hyperreflexia , spinal cord , medicine , endocrinology , anesthesia , antagonist , urinary bladder , receptor , urology , psychiatry
Intrathecal administration of the PAC1 receptor antagonist, PACAP6‐38 (10 nM), significantly ( P ≤ 0.05) reduced intermicturition, threshold and micturition pressures in chronic (3–6 weeks) spinal cord injured rats but intravesical administration (100–300 nM) was without effect. Intrathecal PACAP6‐38 reduced the number and amplitude of nonvoiding bladder contractions observed after spinal cord injury (SCI). PACAP may contribute to detrusor hyperreflexia induced by SCI and PACAP antagonists may be a novel approach to reduce detrusor hyperreflexia after SCI.