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Involvement of Protein Kinase C in the PACAP‐Induced Differentiation of Neural Stem Cells into Astrocytes
Author(s) -
WATANABE JUN,
OHNO FUSAKO,
SHIODA SEIJI,
KIKUYAMA SAKAE,
NAKAYA KAZUYASU,
NAKAJO SHIGEO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.090
Subject(s) - adenylate kinase , neural stem cell , microbiology and biotechnology , protein kinase c , protein kinase a , cyclase , kinase , basal (medicine) , chemistry , cellular differentiation , stem cell , biology , endocrinology , biochemistry , enzyme , gene , insulin
Expression of members of the conventional protein kinase C (cPKC) family in the differentiation of mouse neural stem cells (NSCs) induced by pituitary adenylate cyclase‐activating polypeptide (PACAP) was investigated. In particular, expression of the α and β subtypes of cPKC in NSCs was observed. In response to activation by PACAP, cPKCβ transiently increased twofold by day 2 and returned to basal levels by day 4, suggesting that cPKCβ might be responsible for the differentiation process.