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PACAP Receptor (PAC1‐R) Expression in Rat and Rhesus Monkey Thymus
Author(s) -
TOKUDA N.,
ARUDCHELVAN Y.,
SAWADA T.,
ADACHI Y.,
FUKUMOTO T.,
YASUDA M.,
SUMIDA H.,
SHIODA S.,
FUKUDA T.,
ARIMA A.,
KUBOTA S.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.085
Subject(s) - medulla , receptor , medicine , offspring , endocrinology , biology , chemistry , genetics , pregnancy
The expression of PACAP receptor (PAC1‐R) was investigated in the thymus of rats and rhesus monkeys. In the rat thymus, PAC1‐R positive cells were found in the intermediate type of thymic epithelial cells of the medulla. PAC1‐R‐positive cells were also seen in the thymic medulla of the rhesus monkey. The thymus showed unusual structures in some rhesus monkey dams (F0) and offspring (F1) exposed to 2, 3, 7, 8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD). Additionally, in these rhesus monkeys, PAC1‐R expression was different from that in the control thymus.