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Serotonergic Inhibition of Intense Jumping Behavior in Mice Lacking PACAP ( Adcyap1 −/− )
Author(s) -
SHINTANI NORIHITO,
HASHIMOTO HITOSHI,
TANAKA KAZUHIRO,
KAWAGISHI NAOFUMI,
KAWAGUCHI CHIHIRO,
HATANAKA MICHIYOSHI,
AGO YUKIO,
MATSUDA TOSHIO,
BABA AKEMICHI
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.079
Subject(s) - jumping , serotonin , serotonergic , endocrinology , medicine , cyclase , chemistry , biology , physiology , receptor , stimulation
Genetic manipulation of pituitary adenylate cyclase‐activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP ( Adcyap1 −/− ) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1 −/ − mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild‐type mice and that the selective serotonin (5‐HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5‐hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5‐HT metabolite, 5‐hydroxyindoleacetic acid (5‐HIAA) in Adcyap1 −/ − mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1 −/ − mice, and that jumping behaviour may involve the serotonergic system.