Premium
Neuroprotective Effect of PACAP against Kainic Acid‐Induced Neurotoxicity in Rat Retina
Author(s) -
SEKI TAMOTSU,
NAKATANI MASAYOSHI,
TAKI CHISATO,
SHINOHARA YUKO,
OZAWA MOTOKI,
NISHIMURA SHIGERU,
ITO HIROYUKI,
SHIODA SEIJI
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.074
Subject(s) - kainic acid , neuroprotection , retina , neurotoxicity , adenylate kinase , ganglion , medicine , endocrinology , programmed cell death , neuroscience , chemistry , pharmacology , microbiology and biotechnology , biology , biochemistry , toxicity , apoptosis , receptor , glutamate receptor
Pituitary adenylate cyclase‐activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)‐induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.