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NAP, a Peptide Derived from the Activity‐Dependent Neuroprotective Protein, Modulates Macrophage Function
Author(s) -
QUINTANA FRANCISCO J.,
ZALTZMAN ROY,
FERNANDEZMONTESINOS RAFAEL,
HERRERA JUAN LUIS,
GOZES ILLANA,
COHEN IRUN R.,
POZO DAVID
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.069
Subject(s) - neuroprotection , nap , peptide , macrophage , chemistry , function (biology) , microbiology and biotechnology , biology , pharmacology , biochemistry , neuroscience , in vitro
NAP is an eight‐amino acid neuroprotective peptide NAPVSIPQ; it is the smallest active element derived from the recently cloned activity‐dependent neuroprotective protein (ADNP). NAP readily enters the brain from the blood. It will be important to learn whether NAP, in addition to its neuroprotective activity, also might influence immune‐mediated inflammation. Here, we report that: ( a ) macrophages express ADNP; ( b ) expression of ADNP in macrophages responds to VIP; and ( c ) NAP downregulates the key inflammatory cytokines tumor necrosis factor (TNF‐α), interleukin‐16 (IL‐16), and IL‐12 in macrophages. These findings indicate that ADNP/NAP can play an important role in immune regulation as well as in neuroprotection, which may be mutually related processes.