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The Vasoactive Intestinal Peptide Receptor Turnover in Pulmonary Arteries Indicates an Important Role for VIP in the Rat Lung Circulation
Author(s) -
PETKOV VENTZISLAV,
GENTSCHEVA TEMENUSCHKA,
SCHAMBERGER CHANTAL,
HABERL INES,
ARTL ANDREAS,
ANDREAE FRITZ,
MOSGOELLER WILHELM
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.066
Subject(s) - vasoactive intestinal peptide , vasoactive , lung , receptor , pulmonary hypertension , medicine , endocrinology , ex vivo , in vivo , biology , neuropeptide , microbiology and biotechnology
Abstract: Vasoactive intestinal peptide (VIP) is a potent vasorelaxing peptide that plays a role in lung physiology and possibly in pulmonary hypertension. We investigated the turnover of the VIP receptors on rat pulmonary arteries ex vivo . There was evidence for a fast receptor turnover in pulmonary arteries, which underlines the important role of VIP for the regulation of pulmonary circulation and pulmonary pathology.