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Changes in PACAP Levels in the Central Nervous System after Ovariectomy and Castration
Author(s) -
NEMETH JOZSEF,
TAMAS ANDREA,
JOZSA RITA,
HORVATH JUDIT E.,
JAKAB BALAZS,
LENGVARI ISTVAN,
ARIMURA AKIRA,
LUBICS ANDREA,
REGLÓDI DORA
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1317.063
Subject(s) - castration , medicine , endocrinology , hypothalamus , hormone , thalamus , central nervous system , gonadotropin , adenylate kinase , biology , neuroscience , receptor
The aim of the present article was to investigate the influence of gonadectomy on pituitary adenylate cyclase‐activating polypeptide (PACAP) levels in different brain areas. In males, there seems to be an inverse relationship between gonadotropins and PACAP in the brain in the acute phase of castration: PACAP levels decreased in almost all brain areas examined within the first week after castration. In females, such pattern was observed in the hypothalamus, brain stem, and temporal cortex. In the pituitary, levels decreased only on the first day after ovariectomy, and later, as in the thalamus, increases were observed. Although the pattern of change showed gender differences, our results provide further evidence that levels of gonadotropins and possibly gonadotropin‐releasing hormone influence PACAP levels and that PACAP is involved in the regulation of gonadal functions.